Dual protein kinase and nucleoside kinase modulators for rationally designed polypharmacology

Masitinib, a highly selective protein kinase inhibitor, can sensitise gemcitabine-refractory cancer cell lines when used in combination with gemcitabine. Here we report a reverse proteomic approach that identifies the target responsible for this sensitisation: the deoxycytidine kinase (dCK). Masitin...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Hammam, Kahina, Saez-Ayala, Magali, Rebuffet, Etienne, Gros, Laurent, Lopez, Sophie, Hajem, Berengere, Humbert, Martine, Baudelet, Emilie, Audebert, Stephane, Betzi, Stephane, Lugari, Adrien, Combes, Sebastien, Letard, Sebastien, Casteran, Nathalie, Mansfield, Colin, Moussy, Alain, De Sepulveda, Paulo, Morelli, Xavier, Dubreuil, Patrice
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5681654/
https://ncbi.nlm.nih.gov/pubmed/29127277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01582-5
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