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The kinase polypharmacology landscape of clinical PARP inhibitors

Polypharmacology plays an important role in defining response and adverse effects of drugs. For some mechanisms, experimentally mapping polypharmacology is commonplace, although this is typically done within the same protein class. Four PARP inhibitors have been approved by the FDA as cancer therape...

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שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Sci Rep
Main Authors: Antolin, Albert A., Ameratunga, Malaka, Banerji, Udai, Clarke, Paul A., Workman, Paul, Al-Lazikani, Bissan
פורמט: Artigo
שפה:Inglês
יצא לאור: Nature Publishing Group UK 2020
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC7026418/
https://ncbi.nlm.nih.gov/pubmed/32066817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-59074-4
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