Masitinib (AB1010), a Potent and Selective Tyrosine Kinase Inhibitor Targeting KIT

BACKGROUND: The stem cell factor receptor, KIT, is a target for the treatment of cancer, mastocytosis, and inflammatory diseases. Here, we characterise the in vitro and in vivo profiles of masitinib (AB1010), a novel phenylaminothiazole-type tyrosine kinase inhibitor that targets KIT. METHODOLOGY/PR...

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Autores principales: Dubreuil, Patrice, Letard, Sébastien, Ciufolini, Marco, Gros, Laurent, Humbert, Martine, Castéran, Nathalie, Borge, Laurence, Hajem, Bérengère, Lermet, Anne, Sippl, Wolfgang, Voisset, Edwige, Arock, Michel, Auclair, Christian, Leventhal, Phillip S., Mansfield, Colin D., Moussy, Alain, Hermine, Olivier
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2746281/
https://ncbi.nlm.nih.gov/pubmed/19789626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007258
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