The HIV-1 integrase-LEDGF allosteric inhibitor MUT-A: resistance profile, impairment of virus maturation and infectivity but without influence on RNA packaging or virus immunoreactivity

BACKGROUND: HIV-1 Integrase (IN) interacts with the cellular co-factor LEDGF/p75 and tethers the HIV preintegration complex to the host genome enabling integration. Recently a new class of IN inhibitors was described, the IN-LEDGF allosteric inhibitors (INLAIs). Designed to interfere with the IN-LED...

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Detalhes bibliográficos
Publicado no:Retrovirology
Main Authors: Amadori, Céline, van der Velden, Yme Ubeles, Bonnard, Damien, Orlov, Igor, van Bel, Nikki, Le Rouzic, Erwann, Miralles, Laia, Brias, Julie, Chevreuil, Francis, Spehner, Daniele, Chasset, Sophie, Ledoussal, Benoit, Mayr, Luzia, Moreau, François, García, Felipe, Gatell, José, Zamborlini, Alessia, Emiliani, Stéphane, Ruff, Marc, Klaholz, Bruno P., Moog, Christiane, Berkhout, Ben, Plana, Montserrat, Benarous, Richard
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5680779/
https://ncbi.nlm.nih.gov/pubmed/29121950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12977-017-0373-2
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