Structure-function analyses unravel distinct effects of allosteric inhibitors of HIV-1 integrase on viral maturation and integration

Recently, a new class of HIV-1 integrase (IN) inhibitors with a dual mode of action, called IN-LEDGF/p75 allosteric inhibitors (INLAIs), was described. Designed to interfere with the IN-LEDGF/p75 interaction during viral integration, unexpectedly, their major impact was on virus maturation. This act...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Bonnard, Damien, Le Rouzic, Erwann, Eiler, Sylvia, Amadori, Céline, Orlov, Igor, Bruneau, Jean-Michel, Brias, Julie, Barbion, Julien, Chevreuil, Francis, Spehner, Danièle, Chasset, Sophie, Ledoussal, Benoit, Moreau, François, Saïb, Ali, Klaholz, Bruno P., Emiliani, Stéphane, Ruff, Marc, Zamborlini, Alessia, Benarous, Richard
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5912470/
https://ncbi.nlm.nih.gov/pubmed/29507092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.816793
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