PINK1-mediated phosphorylation of LETM1 regulates mitochondrial calcium transport and protects neurons against mitochondrial stress

Mutations in PTEN-induced kinase 1 (PINK1) result in a recessive familial form of Parkinson’s disease (PD). PINK1 loss is associated with mitochondrial Ca(2+) mishandling, mitochondrial dysfunction, as well as increased neuronal vulnerability. Here we demonstrate that PINK1 directly interacts with a...

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Pubblicato in:Nat Commun
Autori principali: Huang, En, Qu, Dianbo, Huang, Tianwen, Rizzi, Nicoletta, Boonying, Wassamon, Krolak, Dorothy, Ciana, Paolo, Woulfe, John, Klein, Christine, Slack, Ruth S., Figeys, Daniel, Park, David S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5680261/
https://ncbi.nlm.nih.gov/pubmed/29123128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01435-1
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