BAG2 Gene-mediated Regulation of PINK1 Protein Is Critical for Mitochondrial Translocation of PARKIN and Neuronal Survival

Emerging evidence has demonstrated a growing genetic component in Parkinson disease (PD). For instance, loss-of-function mutations in PINK1 or PARKIN can cause autosomal recessive PD. Recently, PINK1 and PARKIN have been implicated in the same signaling pathway to regulate mitochondrial clearance th...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Qu, Dianbo, Hage, Ali, Don-Carolis, Katie, Huang, En, Joselin, Alvin, Safarpour, Farzaneh, Marcogliese, Paul C., Rousseaux, Maxime W. C., Hewitt, Sarah J., Huang, Tianwen, Im, Doo-Soon, Callaghan, Steve, Dewar-Darch, Danielle, Figeys, Daniel, Slack, Ruth S., Park, David S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4683266/
https://ncbi.nlm.nih.gov/pubmed/26538564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.677815
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