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PINK1-dependent phosphorylation of PINK1 and Parkin is essential for mitochondrial quality control

Mitochondrial dysfunction has been linked to the pathogenesis of a large number of inherited diseases in humans, including Parkinson's disease, the second most common neurodegenerative disorder. The Parkinson's disease genes pink1 and parkin, which encode a mitochondrially targeted protein...

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Pubblicato in:Cell Death Dis
Autori principali: Zhuang, Na, Li, Lin, Chen, She, Wang, Tao
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5261015/
https://ncbi.nlm.nih.gov/pubmed/27906179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.396
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