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LOSS OF HYPERDIRECT PATHWAY CORTICO-SUBTHALAMIC INPUTS FOLLOWING DEGENERATION OF MIDBRAIN DOPAMINE NEURONS

The motor symptoms of Parkinson’s disease (PD) are linked to abnormally correlated and coherent activity in the cortex and subthalamic nucleus (STN). However, in parkinsonian mice we found that cortico-STN transmission strength had diminished by 50–75% through loss of axo-dendritic and axo-spinous s...

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Detalhes bibliográficos
Publicado no:Neuron
Main Authors: Chu, Hong-Yuan, McIver, Eileen L., Kovaleski, Ryan F., Atherton, Jeremy F., Bevan, Mark D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5679443/
https://ncbi.nlm.nih.gov/pubmed/28910619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2017.08.038
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