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Age-dependent alterations in meiotic recombination cause chromosome segregation errors in spermatocytes
Faithful chromosome segregation in meiosis requires crossover (CO) recombination, which is regulated to ensure at least one CO per homolog pair. We investigate failure to ensure COs in juvenile male mice. By monitoring recombination genome-wide using cytological assays and at hotspots using molecula...
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| Publicado en: | Cell |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5679441/ https://ncbi.nlm.nih.gov/pubmed/28942922 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.08.042 |
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