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Age-dependent alterations in meiotic recombination cause chromosome segregation errors in spermatocytes

Faithful chromosome segregation in meiosis requires crossover (CO) recombination, which is regulated to ensure at least one CO per homolog pair. We investigate failure to ensure COs in juvenile male mice. By monitoring recombination genome-wide using cytological assays and at hotspots using molecula...

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Detalhes bibliográficos
Publicado no:Cell
Main Authors: Zelazowski, Maciej J., Sandoval, Maria, Paniker, Lakshmi, Hamilton, Holly, Han, Jiaying, Gribbell, Mikalah A., Kang, Rhea, Cole, Francesca
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5679441/
https://ncbi.nlm.nih.gov/pubmed/28942922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.08.042
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