Interspecies Chimerism with Mammalian Pluripotent Stem Cells

Interspecies blastocyst complementation enables organ-specific enrichment of xenogenic pluripotent stem cell (PSC) derivatives. Here, we establish a versatile blastocyst complementation platform based on CRISPR-Cas9-mediated zygote genome editing and show enrichment of rat PSC-derivatives in several...

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Published in:Cell
Main Authors: Wu, Jun, Platero-Luengo, Aida, Sakurai, Masahiro, Sugawara, Atsushi, Gil, Maria Antonia, Yamauchi, Takayoshi, Suzuki, Keiichiro, Bogliotti, Yanina Soledad, Cuello, Cristina, Valencia, Mariana Morales, Okumura, Daiji, Luo, Jingping, Vilariño, Marcela, Parrilla, Inmaculada, Soto, Delia Alba, Martinez, Cristina A., Hishida, Tomoaki, Sánchez-Bautista, Sonia, Martinez-Martinez, M. Llanos, Wang, Huili, Nohalez, Alicia, Aizawa, Emi, Martinez-Redondo, Paloma, Ocampo, Alejandro, Reddy, Pradeep, Roca, Jordi, Maga, Elizabeth A., Esteban, Concepcion Rodriguez, Berggren, W. Travis, Delicado, Estrella Nuñez, Lajara, Jeronimo, Guillen, Isabel, Guillen, Pedro, Campistol, Josep M., Martinez, Emilio A., Ross, Pablo Juan, Belmonte, Juan Carlos Izpisua
Format: Artigo
Language:Inglês
Published: 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5679265/
https://ncbi.nlm.nih.gov/pubmed/28129541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.12.036
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