An NF-κB transcription factor-dependent, lineage specific transcriptional program promotes regulatory T cell identity and function

Both conventional T (Tconv) cells and regulatory T (Treg) cells are activated through ligation of the T cell receptor (TCR) complex, leading to the induction of the transcription factor NF-κB. In Tconv cells, NF-κB regulates expression of genes essential for T cell activation, proliferation and func...

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Veröffentlicht in:Immunity
Hauptverfasser: Oh, Hyunju, Grinberg-Bleyer, Yenkel, Liao, Will, Maloney, Dillon, Wang, Pingzhang, Wu, Zikai, Wang, Jiguang, Bhatt, Dev M., Heise, Nicole, Schmid, Roland M., Hayden, Matthew S., Klein, Ulf, Rabadan, Raul, Ghosh, Sankar
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5679261/
https://ncbi.nlm.nih.gov/pubmed/28889947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2017.08.010
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