Thrombospondin1 (TSP1) replacement prevents cerebral cavernous malformations

KRIT1 mutations are the most common cause of cerebral cavernous malformation (CCM). Acute Krit1 gene inactivation in mouse brain microvascular endothelial cells (BMECs) changes expression of multiple genes involved in vascular development. These changes include suppression of Thbs1, which encodes th...

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Dades bibliogràfiques
Publicat a:J Exp Med
Autors principals: Lopez-Ramirez, Miguel Alejandro, Fonseca, Gregory, Zeineddine, Hussein A., Girard, Romuald, Moore, Thomas, Pham, Angela, Cao, Ying, Shenkar, Robert, de Kreuk, Bart-Jan, Lagarrigue, Frederic, Lawler, Jack, Glass, Christopher K., Awad, Issam A., Ginsberg, Mark H.
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2017
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5679163/
https://ncbi.nlm.nih.gov/pubmed/28970240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20171178
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