Multiplex CRISPR-Cas9 Based Genome Editing in Human Hematopoietic Stem Cells Models Clonal Hematopoiesis and Myeloid Neoplasia

Hematologic malignancies are driven by combinations of genetic lesions that have been difficult to model in human cells. We used CRISPR/Cas9 genome engineering of primary adult and umbilical cord blood CD34+ human hematopoietic stem and progenitor cells (HSPCs), the cells of origin for myeloid pre-m...

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Publicat a:Cell Stem Cell
Autors principals: Tothova, Zuzana, Krill-Burger, John M., Popova, Katerina D., Landers, Catherine C., Sievers, Quinlan L., Yudovich, David, Belizaire, Roger, Aster, Jon C., Morgan, Elizabeth A., Tsherniak, Aviad, Ebert, Benjamin L.
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5679060/
https://ncbi.nlm.nih.gov/pubmed/28985529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2017.07.015
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