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Synthesis of monoalkylidene diketopiperazines and application to the synthesis of barettin()

The synthesis of barettin, a selective serotonin receptor inhibitor and potent antibiofouling natural product, is described. The synthesis starts with the diketopiperazine nucleus intact and the side chains are installed using iterative aldol condensations. The route represents a general strategy fo...

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Pubblicato in:Org Biomol Chem
Autori principali: Kelley, Elizabeth W., Norman, Skylar G., Scheerer, Jonathan R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5678964/
https://ncbi.nlm.nih.gov/pubmed/28980696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7ob02297b
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