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Synthesis of monoalkylidene diketopiperazines and application to the synthesis of barettin()

The synthesis of barettin, a selective serotonin receptor inhibitor and potent antibiofouling natural product, is described. The synthesis starts with the diketopiperazine nucleus intact and the side chains are installed using iterative aldol condensations. The route represents a general strategy fo...

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Detalhes bibliográficos
Publicado no:Org Biomol Chem
Main Authors: Kelley, Elizabeth W., Norman, Skylar G., Scheerer, Jonathan R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5678964/
https://ncbi.nlm.nih.gov/pubmed/28980696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7ob02297b
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