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Synthesis of Pyrrolopyrazinones by Construction of the Pyrrole Ring onto an Intact Diketopiperazine

This study reveals an alternative sequence for the synthesis of compounds that contain the pyrrolodiketopiperazine structural motif. Starting with a diketopiperazine precursor, a mild aldol condensation precedes pyrrole annulation and bicyclic ring fusion. The derived intermediate aldol condensation...

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Publicat a:J Org Chem
Autors principals: Maisto, Susanna K., Leersnyder, Angela P., Pudner, Gwyneth L., Scheerer, Jonathan R.
Format: Artigo
Idioma:Inglês
Publicat: 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7464856/
https://ncbi.nlm.nih.gov/pubmed/32602717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.0c01263
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