Comparative analysis of the GNAQ, GNA11, SF3B1, and EIF1AX driver mutations in melanoma and across the cancer spectrum

Uveal melanoma is characterized by recurrent mutations in GNAQ, GNA11, SF3B1, and EIF1AX, as well as a low total mutational burden. The frequency and clinical significance of these mutations in non-uveal melanoma and other cancers is not well described. We identified that GNAQ/GNA11 mutations occur...

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Detalhes bibliográficos
Publicado no:Pigment Cell Melanoma Res
Main Authors: Johnson, Douglas B., Roszik, Jason, Shoushtari, Alexander N., Eroglu, Zeynep, Balko, Justin, Higham, Catherine, Puzanov, Igor, Patel, Sapna P., Sosman, Jeffrey A., Woodman, Scott E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5678944/
https://ncbi.nlm.nih.gov/pubmed/27089234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/pcmr.12482
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