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Targeting Unoccupied Surfaces on Protein–Protein Interfaces
The use of peptidomimetic scaffolds to target protein–protein interfaces is a promising strategy for inhibitor design. The strategy relies on mimicry of protein motifs that exhibit a concentration of native hot spot residues. To address this constraint, we present a pocket-centric computational desi...
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| Publicado no: | J Am Chem Soc |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5677581/ https://ncbi.nlm.nih.gov/pubmed/28759230 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b05960 |
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