AlphaSpace: Fragment-Centric Topographical Mapping To Target Protein–Protein Interaction Interfaces

[Image: see text] Inhibition of protein–protein interactions (PPIs) is emerging as a promising therapeutic strategy despite the difficulty in targeting such interfaces with drug-like small molecules. PPIs generally feature large and flat binding surfaces as compared to typical drug targets. These fe...

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Bibliografiske detaljer
Udgivet i:J Chem Inf Model
Main Authors: Rooklin, David, Wang, Cheng, Katigbak, Joseph, Arora, Paramjit S., Zhang, Yingkai
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2015
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4550072/
https://ncbi.nlm.nih.gov/pubmed/26225450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jcim.5b00103
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