Glutaredoxin-2 controls cardiac mitochondrial dynamics and energetics in mice, and protects against human cardiac pathologies

Glutaredoxin 2 (GRX2), a mitochondrial glutathione-dependent oxidoreductase, is central to glutathione homeostasis and mitochondrial redox, which is crucial in highly metabolic tissues like the heart. Previous research showed that absence of Grx2, leads to impaired mitochondrial complex I function,...

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Gepubliceerd in:Redox Biol
Hoofdauteurs: Kanaan, Georges N., Ichim, Bianca, Gharibeh, Lara, Maharsy, Wael, Patten, David A., Xuan, Jian Ying, Reunov, Arkadiy, Marshall, Philip, Veinot, John, Menzies, Keir, Nemer, Mona, Harper, Mary-Ellen
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2017
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Research Paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5675898/
https://ncbi.nlm.nih.gov/pubmed/29101900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2017.10.019
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