Cardiac‐specific ablation of glutaredoxin 3 leads to cardiac hypertrophy and heart failure

Abstract Growing evidence suggests that redox‐sensitive proteins including glutaredoxins (Grxs) can protect cardiac muscle cells from oxidative stress‐induced damage. Mammalian Grx3 has been shown to be critical in regulating cellular redox states. However, how Grx3 affects cardiac function by modul...

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Detalhes bibliográficos
Main Authors: Jimmonique Donelson, Qiongling Wang, Tanner O. Monroe, Xiqian Jiang, Jianjie Zhou, Han Yu, Qianxing Mo, Qin Sun, Juan C. Marini, Xinquan Wang, Paul A. Nakata, Kendal D. Hirschi, Jin Wang, George G. Rodney, Xander H.T. Wehrens, Ninghui Cheng
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley 2019-04-01
Colecção:Physiological Reports
Assuntos:
Calcium handling
cardiac hypertrophy
glutaredoxin
heart failure
oxidative stress
Acesso em linha:https://doi.org/10.14814/phy2.14071
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