Glutaredoxin-2 Is Required to Control Oxidative Phosphorylation in Cardiac Muscle by Mediating Deglutathionylation Reactions

Glutaredoxin-2 (Grx2) modulates the activity of several mitochondrial proteins in cardiac tissue by catalyzing deglutathionylation reactions. However, it remains uncertain whether Grx2 is required to control mitochondrial ATP output in heart. Here, we report that Grx2 plays a vital role modulating m...

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Detalhes bibliográficos
Main Authors: Mailloux, Ryan J., Xuan, Jian Ying, McBride, Skye, Maharsy, Wael, Thorn, Stephanie, Holterman, Chet E., Kennedy, Christopher R. J., Rippstein, Peter, deKemp, Robert, da Silva, Jean, Nemer, Mona, Lou, Marjorie, Harper, Mary-Ellen
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Bioenergetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4031535/
https://ncbi.nlm.nih.gov/pubmed/24727547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.550574
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