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A Clinically Meaningful Fetal Hemoglobin Threshold for Children with Sickle Cell Anemia During Hydroxyurea Therapy

Hydroxyurea has proven clinical benefits and is recommended to be offered to all children with sickle cell anemia (SCA), but the optimal dosing regimen remains controversial. Induction of red blood cell fetal hemoglobin (HbF) by hydroxyurea appears to be dose-dependent. However, it is unknown whethe...

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Veröffentlicht in:Am J Hematol
Hauptverfasser: Estepp, Jeremie H., Smeltzer, Matthew P., Kang, Guolian, Li, Chen, Wang, Winfred C., Abrams, Christina, Aygun, Banu, Ware, Russell E., Nottage, Kerri, Hankins, Jane S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5675769/
https://ncbi.nlm.nih.gov/pubmed/28913922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ajh.24906
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