Tau phosphorylation at Alzheimer’s disease-related Ser356 contributes to tau stabilization when PAR-1/MARK activity is elevated

Abnormal phosphorylation of the microtubule-associated protein tau is observed in many neurodegenerative diseases, including Alzheimer’s disease (AD). AD-related phosphorylation of two tau residues, Ser262 and Ser356, by PAR-1/MARK stabilizes tau in the initial phase of mismetabolism, leading to sub...

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Veröffentlicht in:Biochem Biophys Res Commun
Hauptverfasser: Ando, Kanae, Oka, Mikiko, Ohtake, Yosuke, Hayashishita, Motoki, Shimizu, Sawako, Hisanaga, Shin-ichi, Iijima, Koichi M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5675734/
https://ncbi.nlm.nih.gov/pubmed/27520376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2016.08.053
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