Efficacy and Safety of Spironolactone in Acute Heart Failure: The ATHENA-HF Randomized Clinical Trial

IMPORTANCE: Persistent congestion is associated with worse outcomes in acute heart failure (AHF). Mineralocorticoid receptor antagonists administered at high doses may relieve congestion, overcome diuretic resistance, and mitigate the effects of adverse neurohormonal activation in AHF. OBJECTIVE: To...

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Vydáno v:JAMA Cardiol
Hlavní autoři: Butler, Javed, Anstrom, Kevin J., Felker, G. Michael, Givertz, Michael M., Kalogeropoulos, Andreas P., Konstam, Marvin A., Mann, Douglas L., Margulies, Kenneth B., McNulty, Steven E., Mentz, Robert J., Redfield, Margaret M., Tang, W. H. Wilson, Whellan, David J., Shah, Monica, Desvigne-Nickens, Patrice, Hernandez, Adrian F., Braunwald, Eugene
Médium: Artigo
Jazyk:Inglês
Vydáno: American Medical Association 2017
Témata:
Original Investigation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5675712/
https://ncbi.nlm.nih.gov/pubmed/28700781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamacardio.2017.2198
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