Efficacy and Safety of Spironolactone in Acute Heart Failure: The ATHENA-HF Randomized Clinical Trial

IMPORTANCE: Persistent congestion is associated with worse outcomes in acute heart failure (AHF). Mineralocorticoid receptor antagonists administered at high doses may relieve congestion, overcome diuretic resistance, and mitigate the effects of adverse neurohormonal activation in AHF. OBJECTIVE: To...

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Detalhes bibliográficos
Publicado no:JAMA Cardiol
Main Authors: Butler, Javed, Anstrom, Kevin J., Felker, G. Michael, Givertz, Michael M., Kalogeropoulos, Andreas P., Konstam, Marvin A., Mann, Douglas L., Margulies, Kenneth B., McNulty, Steven E., Mentz, Robert J., Redfield, Margaret M., Tang, W. H. Wilson, Whellan, David J., Shah, Monica, Desvigne-Nickens, Patrice, Hernandez, Adrian F., Braunwald, Eugene
Formato: Artigo
Idioma:Inglês
Publicado em: American Medical Association 2017
Assuntos:
Original Investigation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5675712/
https://ncbi.nlm.nih.gov/pubmed/28700781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamacardio.2017.2198
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