Efficacy and Safety of Spironolactone in Acute Heart Failure: The ATHENA-HF Randomized Clinical Trial

IMPORTANCE: Persistent congestion is associated with worse outcomes in acute heart failure (AHF). Mineralocorticoid receptor antagonists administered at high doses may relieve congestion, overcome diuretic resistance, and mitigate the effects of adverse neurohormonal activation in AHF. OBJECTIVE: To...

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Udgivet i:JAMA Cardiol
Main Authors: Butler, Javed, Anstrom, Kevin J., Felker, G. Michael, Givertz, Michael M., Kalogeropoulos, Andreas P., Konstam, Marvin A., Mann, Douglas L., Margulies, Kenneth B., McNulty, Steven E., Mentz, Robert J., Redfield, Margaret M., Tang, W. H. Wilson, Whellan, David J., Shah, Monica, Desvigne-Nickens, Patrice, Hernandez, Adrian F., Braunwald, Eugene
Format: Artigo
Sprog:Inglês
Udgivet: American Medical Association 2017
Fag:
Original Investigation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5675712/
https://ncbi.nlm.nih.gov/pubmed/28700781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamacardio.2017.2198
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