INHIBITION OF THE GLYCOLYTIC ACTIVATOR PFKFB3 IN ENDOTHELIAL CELLS INDUCES TUMOR VESSEL NORMALIZATION, IMPAIRS METASTASIS AND IMPROVES CHEMOTHERAPY

Abnormal tumor vessels promote metastasis and impair chemotherapy. Hence, tumor vessel normalization (TVN) is emerging as anti-cancer treatment. Here, we show that tumor endothelial cells (ECs) have a hyper-glycolytic metabolism, shunting intermediates to nucleotide synthesis. EC haplo-deficiency or...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Cancer Cell
Κύριοι συγγραφείς: Cantelmo, Anna Rita, Conradi, Lena-Christin, Brajic, Aleksandra, Goveia, Jermaine, Kalucka, Joanna, Pircher, Andreas, Chaturvedi, Pallavi, Hol, Johanna, Thienpont, Bernard, Teuwen, Laure-Anne, Schoors, Sandra, Boeckx, Bram, Vriens, Joris, Kuchnio, Anna, Veys, Koen, Cruys, Bert, Finotto, Lise, Treps, Lucas, Stav-Noraas, Tor Espen, Bifari, Francesco, Stapor, Peter, Decimo, Ilaria, Kampen, Kim, De Bock, Katrien, Haraldsen, Guttorm, Schoonjans, Luc, Rabelink, Ton, Eelen, Guy, Ghesquière, Bart, Rehman, Jalees, Lambrechts, Diether, Malik, Asrar B., Dewerchin, Mieke, Carmeliet, Peter
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2016
Θέματα:
Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5675554/
https://ncbi.nlm.nih.gov/pubmed/27866851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2016.10.006
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