INHIBITION OF THE GLYCOLYTIC ACTIVATOR PFKFB3 IN ENDOTHELIAL CELLS INDUCES TUMOR VESSEL NORMALIZATION, IMPAIRS METASTASIS AND IMPROVES CHEMOTHERAPY

Abnormal tumor vessels promote metastasis and impair chemotherapy. Hence, tumor vessel normalization (TVN) is emerging as anti-cancer treatment. Here, we show that tumor endothelial cells (ECs) have a hyper-glycolytic metabolism, shunting intermediates to nucleotide synthesis. EC haplo-deficiency or...

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Publicado no:Cancer Cell
Main Authors: Cantelmo, Anna Rita, Conradi, Lena-Christin, Brajic, Aleksandra, Goveia, Jermaine, Kalucka, Joanna, Pircher, Andreas, Chaturvedi, Pallavi, Hol, Johanna, Thienpont, Bernard, Teuwen, Laure-Anne, Schoors, Sandra, Boeckx, Bram, Vriens, Joris, Kuchnio, Anna, Veys, Koen, Cruys, Bert, Finotto, Lise, Treps, Lucas, Stav-Noraas, Tor Espen, Bifari, Francesco, Stapor, Peter, Decimo, Ilaria, Kampen, Kim, De Bock, Katrien, Haraldsen, Guttorm, Schoonjans, Luc, Rabelink, Ton, Eelen, Guy, Ghesquière, Bart, Rehman, Jalees, Lambrechts, Diether, Malik, Asrar B., Dewerchin, Mieke, Carmeliet, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5675554/
https://ncbi.nlm.nih.gov/pubmed/27866851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2016.10.006
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