Function of Novel Anti-CD19 Chimeric Antigen Receptors with Human Variable Regions Is Affected by Hinge and Transmembrane Domains

Anti-CD19 chimeric antigen receptor (CAR) T cells have caused remissions of B cell malignancies, but problems including cytokine-mediated toxicity and short persistence of CAR T cells in vivo might limit the effectiveness of anti-CD19 CAR T cells. Anti-CD19 CARs that have been tested clinically had...

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Publicado en:Mol Ther
Main Authors: Alabanza, Leah, Pegues, Melissa, Geldres, Claudia, Shi, Victoria, Wiltzius, Jed J.W., Sievers, Stuart A., Yang, Shicheng, Kochenderfer, James N.
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Gene & Cell Therapy 2017
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5675490/
https://ncbi.nlm.nih.gov/pubmed/28807568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2017.07.013
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