Incorporation of a hinge domain improves the expansion of chimeric antigen receptor T cells

BACKGROUND: Multiple iterations of chimeric antigen receptors (CARs) have been developed, mainly focusing on intracellular signaling modules. However, the effect of non-signaling extracellular modules on the expansion and therapeutic efficacy of CARs remains largely undefined. METHODS: We generated...

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Detalhes bibliográficos
Publicado no:J Hematol Oncol
Main Authors: Qin, Le, Lai, Yunxin, Zhao, Ruocong, Wei, Xinru, Weng, Jianyu, Lai, Peilong, Li, Baiheng, Lin, Simiao, Wang, Suna, Wu, Qiting, Liang, Qiubin, Li, Yangqiu, Zhang, Xuchao, Wu, Yilong, Liu, Pentao, Yao, Yao, Pei, Duanqing, Du, Xin, Li, Peng
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Rapid Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5347831/
https://ncbi.nlm.nih.gov/pubmed/28288656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-017-0437-8
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