Multiscale network modeling of oligodendrocytes reveals molecular components of myelin dysregulation in Alzheimer’s disease

BACKGROUND: Oligodendrocytes (OLs) and myelin are critical for normal brain function and have been implicated in neurodegeneration. Several lines of evidence including neuroimaging and neuropathological data suggest that Alzheimer’s disease (AD) may be associated with dysmyelination and a breakdown...

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Veröffentlicht in:Mol Neurodegener
Hauptverfasser: McKenzie, Andrew T., Moyon, Sarah, Wang, Minghui, Katsyv, Igor, Song, Won-Min, Zhou, Xianxiao, Dammer, Eric B., Duong, Duc M., Aaker, Joshua, Zhao, Yongzhong, Beckmann, Noam, Wang, Pei, Zhu, Jun, Lah, James J., Seyfried, Nicholas T., Levey, Allan I., Katsel, Pavel, Haroutunian, Vahram, Schadt, Eric E., Popko, Brian, Casaccia, Patrizia, Zhang, Bin
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5674813/
https://ncbi.nlm.nih.gov/pubmed/29110684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-017-0219-3
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