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Germ-cell specific inflammasome component NLRP14 negatively regulates cytosolic nucleic acid sensing to promote fertilization

Cytosolic sensing of nucleic acids initiates tightly regulated programs to limit infection. Oocyte fertilization represents a scenario when inappropriate responses to exogenous yet non-pathogen-derived nucleic acids would have negative consequences. We hypothesized that germ cells express negative r...

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Detalhes bibliográficos
Publicado no:Immunity
Main Authors: Abe, Takayuki, Lee, Albert, Sitharam, Ramaswami, Kesner, Jordan, Rabadan, Raul, Shapira, Sagi D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5674777/
https://ncbi.nlm.nih.gov/pubmed/28423339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2017.03.020
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