Smad3 initiates oxidative stress and proteolysis that underlies diaphragm dysfunction during mechanical ventilation

Prolonged use of mechanical ventilation (MV) leads to atrophy and dysfunction of the major inspiratory muscle, the diaphragm, contributing to ventilator dependence. Numerous studies have shown that proteolysis and oxidative stress are among the major effectors of ventilator-induced diaphragm muscle...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Tang, Huibin, L. Kennedy, Catherine, Lee, Myung, Gao, Yang, Xia, Hui, Olguin, Francesca, Fraga, Danielle A., Ayers, Kelsey, Choi, Sehoon, Kim, Michael, Tehrani, Amir, Sowb, Yasser A., Rando, Thomas A., Shrager, Joseph B.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5673963/
https://ncbi.nlm.nih.gov/pubmed/29109401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-11978-4
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