A Dementia-Associated Risk Variant near TMEM106B Alters Chromatin Architecture and Gene Expression

Neurodegenerative diseases pose an extraordinary threat to the world’s aging population, yet no disease-modifying therapies are available. Although genome-wide association studies (GWASs) have identified hundreds of risk loci for neurodegeneration, the mechanisms by which these loci influence diseas...

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Detalhes bibliográficos
Publicado no:Am J Hum Genet
Main Authors: Gallagher, Michael D., Posavi, Marijan, Huang, Peng, Unger, Travis L., Berlyand, Yosef, Gruenewald, Analise L., Chesi, Alessandra, Manduchi, Elisabetta, Wells, Andrew D., Grant, Struan F.A., Blobel, Gerd A., Brown, Christopher D., Chen-Plotkin, Alice S.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5673619/
https://ncbi.nlm.nih.gov/pubmed/29056226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2017.09.004
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