TMEM106B, the Risk Gene for Frontotemporal Dementia, Is Regulated by the microRNA-132/212 Cluster and Affects Progranulin Pathways

Frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) is a fatal neurodegenerative disease with no available treatments. Mutations in the progranulin gene (GRN) causing impaired production or secretion of progranulin are a common Mendelian cause of FTLD-TDP; additionally, common varian...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Chen-Plotkin, Alice S., Unger, Travis L., Gallagher, Michael D., Bill, Emily, Kwong, Linda K., Volpicelli-Daley, Laura, Busch, Johanna I., Akle, Sebastian, Grossman, Murray, Van Deerlin, Vivianna, Trojanowski, John Q., Lee, Virginia M.-Y.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Society for Neuroscience 2012
Pynciau:
Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3446826/
https://ncbi.nlm.nih.gov/pubmed/22895706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0521-12.2012
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