Characterization of the radiosynthesis and purification of [(18)F]THK-5351, a PET ligand for neurofibrillary tau

This work characterizes the radiochemical synthesis, purification, and formulation of [(18)F]THK-5351, a tau PET radioligand, and develops an automated radiosynthesis routine (ELIXYS, Sofie Biosciences). Nucleophilic radiofluorination reaction was complete by 7 minutes at 110°C with radiochemical yi...

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Pubblicato in:Appl Radiat Isot
Autori principali: Betthauser, Tobey J, Ellison, Paul A, Murali, Dhanabalan, Lao, Patrick J, Barnhart, Todd E, Furumoto, Shozo, Okamura, Nobuyuki, Johnson, Sterling C, Engle, Jonathan W, Nickles, Robert J, Christian, Bradley T
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5673567/
https://ncbi.nlm.nih.gov/pubmed/29031087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apradiso.2017.10.002
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