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Spontaneous testicular atrophy occurs despite normal spermatogonial proliferation in a Tp53 knockout rat

The tumor suppressor protein p53 (TP53) has many functions in cell cycle regulation, apoptosis, and DNA damage repair, and is also involved in spermatogenesis in the mouse. To evaluate the role of p53 in spermatogenesis in the rat, we characterized testis biology in adult males of a novel p53 knocko...

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Bibliografiske detaljer
Udgivet i:Andrology
Main Authors: Dai, Matthew S., Hall, Susan J., Vantangoli Policelli, Marguerite M., Boekelheide, Kim, Spade, Daniel J.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5673550/
https://ncbi.nlm.nih.gov/pubmed/28834365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/andr.12409
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