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Enzymatic C–H Oxidation-Amidation Cascade in the Production of Natural and Unnatural Thiotetronate Antibiotics with Potentiated Bioactivity
The selective activation of unreactive hydrocarbons by biosynthetic enzymes has inspired new synthetic methods in C–H bond activation. Herein, we report the unprecedented two-step biosynthetic conversion of thiotetromycin to thiotetroamide C involving the tandem oxidation and amidation of an unreact...
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| Опубликовано в: : | Angew Chem Int Ed Engl |
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| Главные авторы: | , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2017
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5673260/ https://ncbi.nlm.nih.gov/pubmed/28833969 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201705239 |
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