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A genomics-led approach to deciphering the mechanism of thiotetronate antibiotic biosynthesis
Thiolactomycin (TLM) is a thiotetronate antibiotic that selectively targets bacterial fatty acid biosynthesis through inhibition of the β-ketoacyl-acyl carrier protein synthases (KASI/II) that catalyse chain elongation on the type II (dissociated) fatty acid synthase. It has proved effective in in v...
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| Publicado no: | Chem Sci |
|---|---|
| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Royal Society of Chemistry
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5518548/ https://ncbi.nlm.nih.gov/pubmed/28791099 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5sc03059e |
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