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Manganese and Cobalt in the Nonheme Metal-binding Site of a Biosynthetic Model of Heme-Copper Oxidase Superfamily Confer Oxidase Activity through Redox-inactive Mechanism

The presence of nonheme metal, such as copper and iron, in the heme-copper oxidase (HCO) superfamily is critical to the enzymatic activity of reducing O(2) to H(2)O, but the exact mechanism the nonheme metal ion uses to confer and fine-tune the activity remains to be understood. We report that manga...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Reed, Julian H., Shi, Yelu, Zhu, Qianhong, Chakraborty, Saumen, Mirts, Evan N., Petrik, Igor D., Bhagi-Damodaran, Ambika, Ross, Matthew, Moënne-Loccoz, Pierre, Zhang, Yong, Lu, Yi
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5673108/
https://ncbi.nlm.nih.gov/pubmed/28768416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b05800
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