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CAT-tailing as a fail-safe mechanism for efficient degradation of stalled nascent polypeptides
Ribosome stalling leads to recruitment of the Ribosome Quality control Complex (RQC), which targets the partially synthesized polypeptide for proteasomal degradation through the action of the ubiquitin ligase Ltn1p. A second core RQC component, Rqc2p, modifies the nascent polypeptide by adding a Car...
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| Publicado no: | Science |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5673106/ https://ncbi.nlm.nih.gov/pubmed/28751611 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aam7787 |
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