Inhibition of IRAK1 Ubiquitination Determines Glucocorticoid Sensitivity for TLR9-Induced Inflammation in Macrophages

Inflammatory responses are controlled by signaling mediators that are regulated by various posttranslational modifications. Recently, transcription-independent functions for glucocorticoids (GC) in restraining inflammation have emerged, but the underlying mechanisms are unknown. In this study, we re...

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Bibliographic Details
Published in:J Immunol
Main Authors: Kong, Fansheng, Liu, Zhiwei, Jain, Viral G., Shima, Kenjiro, Suzuki, Takuji, Muglia, Louis J., Starczynowski, Daniel T., Pasare, Chandrashekhar, Bhattacharyya, Sandip
Format: Artigo
Language:Inglês
Published: AAI 2017
Subjects:
Innate Immunity and Inflammation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5672817/
https://ncbi.nlm.nih.gov/pubmed/29038250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1700443
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