Molecular synergy underlies the co-occurrence patterns and phenotype of NPM1-mutant acute myeloid leukemia

NPM1 mutations define the commonest subgroup of acute myeloid leukemia (AML) and frequently co-occur with FLT3 internal tandem duplications (ITD) or, less commonly, NRAS or KRAS mutations. Co-occurrence of mutant NPM1 with FLT3-ITD carries a significantly worse prognosis than NPM1-RAS combinations....

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Veröffentlicht in:Blood
Hauptverfasser: Dovey, Oliver M., Cooper, Jonathan L., Mupo, Annalisa, Grove, Carolyn S., Lynn, Claire, Conte, Nathalie, Andrews, Robert M., Pacharne, Suruchi, Tzelepis, Konstantinos, Vijayabaskar, M. S., Green, Paul, Rad, Roland, Arends, Mark, Wright, Penny, Yusa, Kosuke, Bradley, Allan, Varela, Ignacio, Vassiliou, George S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2017
Schlagworte:
Myeloid Neoplasia
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5672315/
https://ncbi.nlm.nih.gov/pubmed/28835438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-01-760595
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