Population pharmacokinetics of moxifloxacin and its concentration–QT interval relationship modeling in Chinese healthy volunteers

Moxifloxacin (MX) is an 8-methoxyquinolone antimicrobial drug, which is often used as a positive control in thorough QT (TQT) studies. In the present study we established the population pharmacokinetics model of MX and the relationship of MX concentrations with the QT and various corrected QT (QTc)...

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Publicado en:Acta Pharmacol Sin
Main Authors: Xu, Feng-yan, Huang, Ji-han, He, Ying-chun, Liang, Li-yu, Li, Lu-jin, Yang, Juan, Yin, Fang, Xu, Ling, Zheng, Qing-shan, Wang, Kun
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2017
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5672076/
https://ncbi.nlm.nih.gov/pubmed/28713157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2017.76
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