Saxagliptin Attenuates Albuminuria by Inhibiting Podocyte Epithelial- to-Mesenchymal Transition via SDF-1α in Diabetic Nephropathy

The dipeptidyl peptidase-4 (DPP-4) inhibitor saxagliptin has been found to reduce progressive albuminuria, but the exact mechanism of inhibition is unclear. Podocyte epithelial-to-mesenchymal transition (EMT) has emerged as a potential pathway leading to proteinuria in diabetic nephropathy (DN). Str...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Chang, Yun-peng, Sun, Bei, Han, Zhe, Han, Fei, Hu, Shao-lan, Li, Xiao-yu, Xue, Mei, Yang, Yang, Chen, Li, Li, Chun-jun, Chen, Li-ming
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5672017/
https://ncbi.nlm.nih.gov/pubmed/29163166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00780
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