Distinct Mechanism of Cysteine Oxidation-Dependent Activation and Cold Sensitization of Human Transient Receptor Potential Ankyrin 1 Channel by High and Low Oxaliplatin

Oxaliplatin, a third-generation platinum-based chemotherapeutic agent, displays unique acute peripheral neuropathy triggered or enhanced by cold, and accumulating evidence suggests that transient receptor potential ankyrin 1 (TRPA1) is responsible. TRPA1 is activated by oxaliplatin via a glutathione...

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Bibliographic Details
Published in:Front Physiol
Main Authors: Miyake, Takahito, Nakamura, Saki, Meng, Zhao, Hamano, Satoshi, Inoue, Keisuke, Numata, Tomohiro, Takahashi, Nobuaki, Nagayasu, Kazuki, Shirakawa, Hisashi, Mori, Yasuo, Nakagawa, Takayuki, Kaneko, Shuji
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2017
Subjects:
Physiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5672011/
https://ncbi.nlm.nih.gov/pubmed/29163216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2017.00878
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