Cold sensitivity of TRPA1 is unveiled by the prolyl hydroxylation blockade-induced sensitization to ROS

Mammalian transient receptor potential ankyrin 1 (TRPA1) is a polymodal nociceptor that plays an important role in pain generation, but its role as a cold nociceptor is still controversial. Here, we propose that TRPA1 can sense noxious cold via transduction of reactive oxygen species (ROS) signallin...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Nat Commun
Autors principals: Miyake, Takahito, Nakamura, Saki, Zhao, Meng, So, Kanako, Inoue, Keisuke, Numata, Tomohiro, Takahashi, Nobuaki, Shirakawa, Hisashi, Mori, Yasuo, Nakagawa, Takayuki, Kaneko, Shuji
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5027619/
https://ncbi.nlm.nih.gov/pubmed/27628562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12840
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars