Cold sensitivity of TRPA1 is unveiled by the prolyl hydroxylation blockade-induced sensitization to ROS

Mammalian transient receptor potential ankyrin 1 (TRPA1) is a polymodal nociceptor that plays an important role in pain generation, but its role as a cold nociceptor is still controversial. Here, we propose that TRPA1 can sense noxious cold via transduction of reactive oxygen species (ROS) signallin...

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Udgivet i:Nat Commun
Main Authors: Miyake, Takahito, Nakamura, Saki, Zhao, Meng, So, Kanako, Inoue, Keisuke, Numata, Tomohiro, Takahashi, Nobuaki, Shirakawa, Hisashi, Mori, Yasuo, Nakagawa, Takayuki, Kaneko, Shuji
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5027619/
https://ncbi.nlm.nih.gov/pubmed/27628562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12840
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